Minny/Minny 28 Drug Interactions

Anticoagulants: Oral contraceptive can increase levels of certain circulating clotting factors and reduce Antithrombin III levels, therapeutic efficacy of the anticoagulants may be decrease. However, both an increased and decreased effect has occurred.
Antidepressants, Tricyclic, Beta blockers, caffeine, corticosteriods, theophyllines: The hepatic metabolism of these agents may be decrease, resulting in increased therapeutic effects or toxicity.
Benzodiazepines: Oral contraceptives may increase the clearance of the benzodiazepines that undergo glucuronidation (e.g. lorazepam, oxazepam, temazepam) because of increased metabolism. Combination oral contraceptives with alprazolam, chlordiazepoxide, diazepam, and triazolam may inhibit hepatic mixed-function oxidases leading to a decrease in benzodiazepines oxidation rate (may prolong the half-life of benzodiazepines).
Both an increased and decreased effect has occurred.
Antibiotics: Coadministration of griseofulvin, penicillins, or tetracyclines with oral contraceptives (OCs), may decrease the pharmacologic effect of the oral contraceptives, possibly because of altered steroid gut metabolism secondary to changes in the intestinal flora. Mentrual irregularities and pregnancy may occur.
An alternate or additional form of birth control may be advisable during concomitant use.
Barbiturates, Carbamazepine, Hydantoins, Phenytoin, Rifamycins, St. John's wort: These agents may increase the hepatic metabolism of the oral contraceptives via hepatic microsomal enzyme induction, possible resulting in decreased effectiveness of the oral contraceptives.
Menstrual irregularities and pregnancy may occur. An alternate or additional form of birth control may be advisable during concomitant use.